Won a Tony for Best Performance by a Leading Actor in a Musical for "Curtains" in 2007.

Pierce resides in Los Angeles with his longtime partner TV writer/director/producer Brian Hargrove.

Has played Kelsey Grammer`s brother twice: on "Frasier" (1993) and on `The (1997) Simpsons: Brother From Another Series`. John Mahoney also played the father of both pairs of characters.

One year when he was performing at the international comedy festival "Just for Laughs", he arrived in Montreal for check-in with the festival exhausted and disheveled. He remarked to one of the festival workers how he was looking forward to resting in his hotel room. The worker replied with empathy, saying how tired they were working overtime with few breaks trying to tie up the lose ends and help the performers before the comedy routines. Moments later, Pierce returned with fresh coffee and pastries for all those working at the Festival`s check-in.

Asked not to be credited as the voice of Abe Sapien in Hellboy (2004) because he felt the characterization of Abe truly belonged to Doug Jones (the actor who played Abe on the set).

Made his debut with the New York Philaharmonic in April 2003 in the role of Benedict, in the concert staging of Berlioz`s opera Beatrice and Benedict. Harriet Harris, (Agent Bebe Glazer on Frasier) played Beatrice opposite Pierce.

He kickboxes.

Once sold ties at Bloomingdales in New York.

Attended Yale with Jodie Foster. When she was preparing to direct Little Man Tate (1991), she remembered him from a play he was in at that time and called and offered him a part.

Graduated from Yale University with a double major in English and theater arts.

Holds the record for being nominated for most Best Supporting Actor Emmys for a character, Dr. Niles Crane on "Frasier". He was nominated 11 times.

Is active in the fight to find a cure for Alzheimer`s, which his grandfather suffered from.

Once worked as a security guard.

He received his initial interview with the creators of "Frasier" (1993) due to his close resemblance to Kelsey Grammer. After the interview, the part of Niles Crane was written for him.

Attended Bethesda Episcopal Church in Saratoga Springs.

Plays both the piano and the organ.

Received the Yaddo Medal as best dramatic arts student upon graduation from Saratoga Springs High School, 1977.