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Isaac Seneca is a member of the following lists: Greensburg Athletic Association players, Players of American football from New York and Carlisle Indian Industrial School alumni.
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7th October, 1874
Cattaraugus Reservation, Cattaraugus County, New York
Isaac Seneca, Jr. (October 7, 1874 – 1945) was an All-American football player for the Carlisle Indian Industrial School. He was selected as an All-American halfback on the 1899 College Football All-America Team. He was the first Carlisle player and the first American Indian to be selected as an All-American. He was born in 1874 on the Cattaraugus Reservation in New York.