Miko was born in San Diego, to Vietnamese and Chinese parents. According to various sources, San Diego is where she spent the majority of her childhood growing up.
Miko began her career as an adult model around 1999-2000 when she started to appear in various adult picture layouts, which were distributed through various adult websites. Her career as an adult actress began in 2000 as she started to appear in mostly Asian themed adult flicks. In the beginning of her career, she was known for being a buxom figured Asian girl with a round face.
Since her first adult film in 1999, Miko has appeared in numerous movies, many of which feature her in the title role, such as Cruising With Miko Lee and My Plaything: Miko Lee. The latter was a "virtual" or "interactive" DVD devoted to Miko.