| Screen Directors Playhouse | 1955 | Selma | TV Show |
| The 20th Century-Fox Hour | 1955 | Miss Appleton | TV Show |
| Francis Joins the WACS | 1954 | Lt. Valerie Humpert | Movie |
| The Best of Broadway | 1954 | Miss Preen | TV Show |
| G.E. True Theater | 1953 | Aunt Laura | TV Show |
| Private Secretary | 1953 | Aunt Martha | TV Show |
| Denver and Rio Grande | 1952 | Jane Dwyer | Movie |
| The Red Skelton Hour | 1951 | Ma Raspin | TV Show |
| Francis | 1950 | Nurse Valerie Humpert | Movie |
| Lum and Abner | 1949 | | TV Movie |
| The Philco-Goodyear Television Playhouse | 1948 | Belinda Pryde | TV Show |
| The Chevrolet Tele-Theatre | 1948 | | TV Show |
| Life with Father | 1947 | Cora | Movie |
| Kraft Theatre | 1947 | | TV Show |
| Breakfast in Hollywood | 1946 | Elvira Spriggens | Movie |
| The Perfect Marriage | 1946 | Rosa | Movie |
| Dear Miss Gloria | 1946 | Guest star (uncredited) | Short Film |
| Let's Face It | 1943 | Cornelia Figeson | Movie |
| The Bashful Bachelor | 1942 | Geraldine (as ZaSu Pitts) | Movie |
| Mexican Spitfire at Sea | 1942 | Miss Pepper | Movie |
| So's Your Aunt Emma! | 1942 | Aunt Emma Bates | Movie |
| Tish | 1942 | Aggie Pilkington (as ZaSu Pitts) | Movie |
| Broadway Limited | 1941 | Myra Pottle | Movie |
| The Mexican Spitfire's Baby | 1941 | Miss Emily Pepper | Movie |
| Niagara Falls | 1941 | Emmy Sawyer | Short Film |
| Miss Polly | 1941 | Miss Polly | Movie |
| Uncle Joe | 1941 | Julia Jordan | Movie |
| Weekend for Three | 1941 | Anna | Movie |
| It All Came True | 1940 | Miss Flint | Movie |
| No, No, Nanette | 1940 | Pauline Hastings | Movie |
| Eternally Yours | 1939 | Mrs. Cary Bingham | Movie |
| Naughty But Nice | 1939 | Aunt Penelope Hardwick | Movie |
| Nurse Edith Cavell | 1939 | Mme. Moulin | Movie |
| The Lady's from Kentucky | 1939 | Dulcey Lee | Movie |
| Mickey the Kid | 1939 | Lilly Handy | Movie |
| Forty Naughty Girls | 1937 | Hildegarde Withers | Movie |
| 52nd Street | 1937 | Letitia Rondell | Movie |
| Merry Comes to Town | 1937 | Winnie Oatfield | Movie |
| Wanted! | 1937 | Winnie Oatfield | Movie |
| Sing Me a Love Song | 1936 | Gwen Logan | Movie |
| The Plot Thickens | 1936 | Hildegarde Withers | Movie |
| Thirteen Hours by Air | 1936 | Miss Harkins | Movie |
| Mad Holiday | 1936 | Mrs. Kinney | Movie |
| Ruggles of Red Gap | 1935 | Prunella Judson (as ZaSu Pitts) | Movie |
| Going Highbrow | 1935 | Mrs. Upshaw | Movie |
| The Affair of Susan | 1935 | Susan Todd | Movie |
| Hot Tip | 1935 | Belle McGill | Movie |
| She Gets Her Man | 1935 | Esmeralda | Movie |
| Spring Tonic | 1935 | Maggie Conklin | Movie |
| Dames | 1934 | Mathilda | Movie |
| Mrs. Wiggs of the Cabbage Patch | 1934 | Miss Hazy (as ZaSu Pitts) | Movie |
| Sing and Like It | 1934 | Annie Snodgrass | Movie |
| The Gay Bride | 1934 | Mirabelle | Movie |
| Two Alone | 1934 | Esthey Roberts | Movie |
| Love Birds | 1934 | Araminta Tootle | Movie |
| The Meanest Gal in Town | 1934 | Tillie Prescott | Movie |
| Private Scandal | 1934 | Miss Coates (as ZaSu Pitts) | Movie |
| Their Big Moment | 1934 | Tillie Whim | Movie |
| Three on a Honeymoon | 1934 | Alice Mudge | Movie |
| Hello, Sister! | 1933 | Millie | Movie |
| Meet the Baron | 1933 | Zasu - Upstairs Maid | Movie |
| Professional Sweetheart | 1933 | Elmerada de Leon | Movie |
| Aggie Appleby, Maker of Men | 1933 | Sybby 'Sib' | Movie |
| Her First Mate | 1933 | Mary Horner | Movie |
| Mr. Skitch | 1933 | Mrs. Maddie Skitch | Movie |
| Out All Night | 1933 | Bonny | Movie |
| One Track Minds | 1933 | Zasu Pitts | Short Film |
| Asleep in the Feet | 1933 | Zasu Pitts | Short Film |
| The Bargain of the Century | 1933 | Zasu Pittts | Short Film |
| Maids a la Mode | 1933 | Miss Pitts | Short Film |
| Love, Honor and Oh, Baby! | 1933 | Connie Clark | Movie |
| Back Street | 1932 | Mrs. Dole (as Za Su Pitts) | Movie |
| Blondie of the Follies | 1932 | Gertie | Movie |
| Broken Lullaby | 1932 | Anna, Holderlin's Maid | Movie |
| Destry Rides Again | 1932 | Temperance Worker | Movie |
| Make Me a Star | 1932 | Mrs. Scudder (as ZaSu Pitts) | Movie |
| Once in a Lifetime | 1932 | Miss Leighton | Movie |
| Shopworn | 1932 | Dot | Movie |
| The Crooked Circle | 1932 | Nora Rafferty | Movie |
| Is My Face Red? | 1932 | Morning Gazette Telephone Operator | Movie |
| Madison Sq. Garden | 1932 | Florrie | Movie |
| Roar of the Dragon | 1932 | Gabby Woman | Movie |
| Strangers of the Evening | 1932 | Sybil Smith | Movie |
| The Trial of Vivienne Ware | 1932 | Gladys Fairweather | Movie |
| They Just Had to Get Married | 1932 | Molly Hull | Movie |
| Westward Passage | 1932 | Mrs. Truesdale | Movie |
| Show Business | 1932 | Zasu Pitts | Short Film |
| Alum and Eve | 1932 | Zasu | Short Film |
| The Old Bull | 1932 | Zasu | Short Film |
| Red Noses | 1932 | Miss Pitts | Short Film |
| Seal Skins | 1932 | Zasu Pitts | Short Film |
| Sneak Easily | 1932 | Miss Zasu Pitts - Woman of the Jury | Short Film |
| The Soilers | 1932 | Zasu | Short Film |
| Steady Company | 1932 | Dot | Movie |
| Strictly Unreliable | 1932 | Pitts | Short Film |
| The Vanishing Frontier | 1932 | Aunt Sylvia (as ZaSu Pitts) | Movie |
| The Unexpected Father | 1932 | Polly Perkins | Movie |
| Seed | 1931 | Jennie | Movie |
| Bad Sister | 1931 | Minnie | Movie |
| The Guardsman | 1931 | Liesl | Movie |
| A Woman of Experience | 1931 | Katie | Movie |
| Penrod and Sam | 1931 | Mrs. Bassett | Movie |
| On the Loose | 1931 | Zasu Pitts | Short Film |
| Beyond Victory | 1931 | 'Mlle' Fritzi Mobley (as ZaSu Pitts) | Movie |
| The Big Gamble | 1931 | Nora Dugan | Movie |
| Catch as Catch Can | 1931 | Zasu | Short Film |
| Let's Do Things | 1931 | Zasu Pitts | Short Film |
| The Pajama Party | 1931 | Zasu Pitts | Short Film |
| The Secret Witness | 1931 | Bella | Movie |
| War Mamas | 1931 | Zasu | Short Film |
| Finn and Hattie | 1931 | Mrs. Haddock | Movie |
| Their Mad Moment | 1931 | Miss Dibbs | Movie |
| All Quiet on the Western Front | 1930 | Frau Bäumer - Silent Version Trailer only (scenes deleted) | Movie |
| Monte Carlo | 1930 | Bertha | Movie |
| Passion Flower | 1930 | Mrs. Harney | Movie |
| Sin Takes a Holiday | 1930 | Annie | Movie |
| The Devil's Holiday | 1930 | Ethel | Movie |
| Honey | 1930 | Mayme | Movie |
| Little Accident | 1930 | Monica | Movie |
| No, No, Nanette | 1930 | Pauline Hastings | Movie |
| River's End | 1930 | Louise | Movie |
| The Lottery Bride | 1930 | Hilda | Movie |
| War Nurse | 1930 | Cushie | Movie |
| Free Love | 1930 | Ada, the Maid | Movie |
| The Squealer | 1930 | Bella | Movie |
| The Locked Door | 1929 | Telephone Girl (as Zazu Pitts) | Movie |
| Paris | 1929 | Harriet | Movie |
| The Dummy | 1929 | Rose Gleason | Movie |
| The Squall | 1929 | Lena | Movie |
| This Thing Called Love | 1929 | Clara Bertrand | Movie |
| The Argyle Case | 1929 | Mrs. Wyatt | Movie |
| Her Private Life | 1929 | Timmins | Movie |
| Oh, Yeah! | 1929 | The Elk | Movie |
| Twin Beds | 1929 | Tillie | Movie |
| The Wedding March | 1928 | Cecelia Schweisser | Movie |
| 13 Washington Square | 1928 | Mathilde | Movie |
| Sins of the Fathers | 1928 | Mother Spengler | Movie |
| The Honeymoon | 1928 | Caecilia | Movie |
| Buck Privates | 1928 | Hulda | Movie |
| Wife Savers | 1928 | Germaine | Movie |
| Sunlight | 1928 | The Younger Sister | Short Film |
| Casey at the Bat | 1927 | Camille Gibson | Movie |
| Mannequin | 1926 | Annie Pogani | Movie |
| Sunny Side Up | 1926 | Evelyn | Movie |
| What Happened to Jones? | 1926 | Hilda (as Zazu Pitts) | Movie |
| Early to Wed | 1926 | Mrs. Dugan | Movie |
| Her Big Night | 1926 | Gladys Smith | Movie |
| Monte Carlo | 1926 | Hope Durant | Movie |
| Risky Business | 1926 | Agnes Wheaton | Movie |
| Pretty Ladies | 1925 | Maggie Keenan | Movie |
| The Business of Love | 1925 | Miss Wright | Movie |
| The Great Divide | 1925 | Polly Jordan | Movie |
| The Great Love | 1925 | Nancy | Movie |
| Lazybones | 1925 | Ruth Fanning | Movie |
| Old Shoes | 1925 | | Movie |
| The Re-Creation of Brian Kent | 1925 | Judy | Movie |
| Thunder Mountain | 1925 | Mandy Coulter | Movie |
| Wages for Wives | 1925 | Luella Logan | Movie |
| A Woman's Faith | 1925 | Blanche Odile | Movie |
| Greed | 1924 | Trina | Movie |
| Wine of Youth | 1924 | Lucy (scenes deleted) | Movie |
| Changing Husbands | 1924 | Delia | Movie |
| Daughters of Today | 1924 | Lorena | Movie |
| The Fast Set | 1924 | Mona | Movie |
| The Goldfish | 1924 | Amelia Pugsley | Movie |
| Legend of Hollywood | 1924 | Mary Brown | Movie |
| Secrets of the Night | 1924 | Celia Stebbins | Movie |
| Triumph | 1924 | A Factory Girl | Movie |
| Sunlight of Paris | 1924 | | Movie |
| Hollywood | 1923 | Zasu Pitts | Movie |
| Souls for Sale | 1923 | Zasu Pitts | Movie |
| Mary of the Movies | 1923 | Zasu Pitts (uncredited) | Movie |
| Poor Men's Wives | 1923 | Apple Annie | Movie |
| Tea: With a Kick! | 1923 | 'Brainy' Jones | Movie |
| Three Wise Fools | 1923 | Mickey | Movie |
| West of the Water Tower | 1923 | Dessie Arnhalt | Movie |
| The Girl Who Came Back | 1923 | Anastasia Muldoon | Movie |
| A Daughter of Luxury | 1922 | Mary Cosgrove | Movie |
| For the Defense | 1922 | Jennie Dunn | Movie |
| Is Matrimony a Failure? | 1922 | Mrs. Wilbur | Movie |
| Youth to Youth | 1922 | Emily | Movie |
| Patsy | 1921 | Patsy | Movie |
| Bright Skies | 1920 | Sally | Movie |
| Heart of Twenty | 1920 | Katie Abbott | Movie |
| Seeing It Through | 1920 | Betty Lawrence | Movie |
| As the Sun Went Down | 1919 | Sal Sue | Movie |
| Better Times | 1919 | Nancy Scroggs | Movie |
| Men, Women, and Money | 1919 | Katie Jones | Movie |
| The Other Half | 1919 | Jennie Jones - The Jazz Kid | Movie |
| Poor Relations | 1919 | Daisy Perkins | Movie |
| The Greatest Thing in Life | 1918 | Undetermined Secondary Role (scenes deleted) | Movie |
| A Society Sensation | 1918 | Mary | Short Film |
| How Could You, Jean? | 1918 | Oscar's Sweetheart | Movie |
| A Lady's Name | 1918 | Emily | Movie |
| The Talk of the Town | 1918 | | Movie |
| The Pie Eyed Piper | 1918 | The Fair Ellen | Short Film |
| Who's Your Wife? | 1918 | Bess | Short Film |
| Rebecca of Sunnybrook Farm | 1917 | Undetermined Role (uncredited) | Movie |
| The Little Princess | 1917 | Becky | Movie |
| A Modern Musketeer | 1917 | A Kansas Belle (uncredited) | Movie |
| '49-'17 | 1917 | Party Guest (uncredited) | Movie |
| Battling Bellboy, The | 1917 | The Chambermaid | Short Film |
| Behind the Map | 1917 | The Schoolteacher | Short Film |
| Canning the Cannibal King | 1917 | Priscilla Potts - the Missionary | Short Film |
| He Had 'em Buffaloed | 1917 | Hepsabiah Hardlot | Short Film |
| His Fatal Beauty | 1917 | Perscilla | Short Film |
| O-My the Tent Mover | 1917 | Saharah Sarah | Short Film |
| Tillie of the Nine Lives | 1917 | | Short Film |
| Uneasy Money | 1917 | Suza - the Editor's Assistant | Short Film |
| Why They Left Home | 1917 | Mary Mandrake | Short Film |
| Desert Dilemma, A | 1917 | | Short Film |
| Discords in 'A' Flat | 1917 | | Short Film |
| A Match in Quarantine | 1917 | | Short Film |
