| Eleven Eleven | 2019 | Burns (voice) | Movie |
| The Casagrandes | 2019 | Father of the Bride | TV Show |
| Where's Waldo? | 2019 | Additional Voices | TV Show |
| Marvel Dimension of Heroes | 2019 | Black Panther, Ronan (voice) | Unknown |
| Beastars | 2019 | Ibuki | TV Show |
| Far Cry 5 | 2018 | (voice) | Unknown |
| LEGO Marvel Super Heroes: Black Panther - Trouble in Wakanda | 2018 | Black Panther (voice), T'Challa | TV Show |
| Baki | 2018 | Additional Cast | TV Show |
| Imaginary Friends | 2017 | Toogie | Short Film |
| Marvel vs. Capcom: Infinite | 2017 | Black Panther (voice) | Unknown |
| Marvel Future Avengers | 2017 | Black Panther | TV Show |
| The Division | 2016 | Combat Medic (voice) (as James C. Mathis III), Shotgun Rusher | Unknown |
| Mafia III | 2016 | Additional Voices (voice) | Unknown |
| Lego Marvel's Avengers | 2016 | Black Panther (voice) (as James Mathis), Malekith the Accursed | Unknown |
| Call of Duty: Infinite Warfare | 2016 | (voice) (as James C Mathis) | Unknown |
| Marvel: Earth's Mightiest Show | 2016 | Self | TV Show |
| Disney Infinity 3.0 | 2015 | Black Panther, Ronan the Accuser (voice) | Unknown |
| Star Wars: The Old Republic - Knights of the Fallen Empire | 2015 | Jom Vanten, Sergeant Ahkar, Sith Lord (voice) | Unknown |
| The Last of Us: Left Behind | 2014 | Additional Voices (voice) | Unknown |
| Disney Infinity: Marvel Super Heroes | 2014 | Ronan the Accuser (voice) | Unknown |
| The Marvel Experience | 2014 | Black Panther (voice) (as James C. Mathis III) | Movie |
| Sleeping Dogs: Definitive Edition | 2014 | King (voice) | Unknown |
| Big Ass Spider! | 2013 | Street Cop | Movie |
| Hulk and the Agents of S.M.A.S.H. | 2013 | Ronan the Accuser | TV Show |
| Avengers Assemble | 2013 | Black Panther | TV Show |
| Grand Theft Auto V | 2013 | The Local Population (voice) | Unknown |
| Marvel Heroes | 2013 | Black Panther, Luke Cage (voice) (as James Mathis), War Machine | Unknown |
| Saints Row IV | 2013 | The Voices of Virtual Steelport (voice) (as James Mathis) | Unknown |
| Ultimate Spider-Man | 2012 | Terrax | TV Show |
| Sleeping Dogs | 2012 | King (voice) (as James Mathis) | Unknown |
| Marvel Pinball: Avengers Chronicles | 2012 | Luke Cage (voice) | Unknown |
| Dead Island | 2011 | Matutero, Various Characters (voice) (as James Mathis) | Unknown |
| inFamous 2 | 2011 | Male Pedestrians (voice) (as James C. Mathis III) | Unknown |
| Shadows of the Damned | 2011 | Beast, Demons (voice), X | Unknown |
| Saints Row: The Third | 2011 | Pedestrian and Character Voices (voice) (as James Mathis) | Unknown |
| Operation Flashpoint: Red River | 2011 | Col. Daniel Taylor (voice) (as James C. Mathis III) | Unknown |
| The Avengers: Earth's Mightiest Heroes | 2010 | Black Panther | TV Show |
| Gillian in Georgia | 2010 | Cedric | TV Show |
| Suitemates | 2010 | Tom | TV Show |
| Metal Gear Solid: Peace Walker | 2010 | Soldiers (voice) (as James C. Mathis III) | Unknown |
| NFL Rush Zone | 2010 | Chiefs Rusher | TV Show |
| Star Wars: The Clone Wars | 2008 | Captain Typho | TV Show |
| Street Warrior | 2008 | Zeke | TV Movie |
| Smiley Face | 2007 | Hippie #2 | Movie |
| I Hate My 30's | 2007 | Bruce (8 episodes, 2007) | TV Show |
| WordGirl | 2007 | Tiny Big | TV Show |
| Paved with Good Intentions | 2006 | Winston | Movie |
| Dead Rising | 2006 | Additional Voices (voice: English version) (as James Mathis), Reginald Jenkins | Unknown |
| Metal Gear Solid: Portable Ops | 2006 | Sigint (voice) (as James Mathis) | Unknown |
| Saints Row | 2006 | Stilwater's Resident (voice) (as James Mathis) | Unknown |
| Scarface: The World Is Yours | 2006 | Donut King (voice) | Unknown |
| Ben 10 | 2005 | Enforcer Alien | TV Show |
| Noah's Arc | 2005 | Malik | TV Show |
| Fantastic Four | 2005 | Additional Voices (voice) (as James Mathis), Puppetmaster | Unknown |
| Shadow of Rome | 2005 | Gedo (voice: English version) (as James Mathis), Zedo | Unknown |
| The Matrix: Path of Neo | 2005 | Police, Security (voice) | Unknown |
| Ultimate Spider-Man | 2005 | (voice) (as James C. Mathis III) | Unknown |
| Metal Gear Solid 3: Snake Eater | 2004 | Sigint (voice) (as James Mathis) | Unknown |
| World of Warcraft | 2004 | (voice) | Unknown |
| Undercover Brother | 2002 | GFC Announcer (voice) (as James C. Mathis III) | Movie |
| Flatland | 2002 | D. Walker | TV Show |
| Monk | 2002 | Rastafarian Cook | TV Show |
| Judging Amy | 1999 | Gordon Parker | TV Show |
| Celebrity Deathmatch | 1998 | Master P. | TV Show |
| Guys Like Us | 1998 | Kyle | TV Show |
| The King of Queens | 1998 | Tony | TV Show |
| Pacific Blue | 1996 | Dominic Bolivar | TV Show |
| ER | 1994 | Darrel, Transpo Tech | TV Show |
| Who Shot Pat? | 1989 | Extra (as James C. Mathis III) | Movie |
