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Amy Mainzer (born 1974) is an American astronomer, specializing in astrophysical instrumentation and infrared astronomy. She is the Deputy Project Scientist for the Wide-field Infrared Survey Explorer and the Principal Investigator for the NEOWISE project to study minor planets. She has appeared a number of times in the History Channel series The Universe. She also appears in the documentary featurette "Stellar Cartography: On Earth" included on the Star Trek Generations home video release (March 2010).