Lawerence Winchester Wetherby (January 2, 1908 – March 27, 1994) was a politician from the US state of Kentucky. After graduating from the University of Louisville, he rose through the judicial system of Jefferson County and was elected lieutenant governor in 1947, serving under Governor Earle C. Clements. He was called Kentucky's first "working" lieutenant governor because, in addition to his constitutional duties in the Kentucky Senate, Clements also asked Wetherby to shoulder other duties such as preparing the state budget and attending the Southern Governors Conference. In 1950, Clements resigned as governor to assume a seat in the U.S. Senate, elevating Wetherby as the 48th Governor. He remains the only person born in Jefferson County to ascend to the governorship, despite the fact that Louisville, the county seat, is the state's most populous city.