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Don't Give Up on Us is a 2006 romantic comedy film, made in the Philippines and directed by Joyce Bernal. The film was the fifth appearance of Judy Ann Santos and Piolo Pascual after Esperanza, Kahit Isang Saglit, Bakit 'Di Totohanin, and Till There Was You, not including two cameos in Pera o Bayong: The Movie and Jologs.