In the television show and the book, Beezus explains that her name is Beatrice. When Ramona started talking as an infant, she couldn't say "Beatrice". She said "Beezus" instead. (imdb.com)
Beezus and Ramona first appeared, as supporting characters, in a series of books focused on Henry Huggins. Beverly Cleary later wrote Beezus and Ramona, which actually focused on Beezus and her family. However, her younger sister Ramona became so popular, that the remaining books focused on Ramona. Beezus is still an important character, and Henry Huggins still appears, but became a secondary character in the series he launched. The names are reversed in the title for this film because of the shift in focus to Ramona. (imdb.com)
The name of the construction company that builds the Quimby's new bedroom is called Bendix, a reference to the name of the doll that Ramona bakes into Beezus' birthday cake in the book "Beezus and Ramona". (imdb.com)
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