Alfred L. Goldberg American Biologist
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Alfred L. Goldberg is a member of the following lists: 1942 births, People from Providence, Rhode Island and Fellows of the American Academy of Arts and Sciences.
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Details
| Alternative Name |
Alfred L. Goldberg
|
| Birthday |
30th November, 1941
|
| Died |
18th April, 2023
|
| Nationality |
American
|
| Occupation |
Biologist
|
Alfred “Fred” Goldberg, Ph.D., (1942-April 18, 2023) was an American cell biologist-biochemist and professor at Harvard University. His major discoveries have concerned the mechanisms and physiological importance of protein degradation in cells. Of wide impact have been his lab's demonstration that all cells contain a pathway for selectively eliminating misfolded proteins, his discoveries about the role of proteasomes in this process and of the enzyme systems catalyzing protein breakdown in bacteria, his elucidating the mechanisms for muscle atrophy and the role of proteasomes in antigen presentation to the immune system, and his introduction of proteasome inhibitors now widely used as research tools and in the treatment of blood cancers.
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