It was at Columbia University that Carr befriended Allen Ginsberg in the Union Theological Seminary dormitory on West 122nd Street (an overflow residence for Columbia at the time), when Ginsberg knocked on the door to find out who was playing a recording of a Brahms trio. Soon after, a young woman Carr had befriended, Edie Parker, introduced Carr to her boyfriend, Jack Kerouac, then twenty-two and nearing the end of his short career as a sailor. Carr, in turn, introduced Ginsberg and Kerouac to one another – and both of them to his older friend with more first-hand experience at decadence: William Burroughs. The core of the New York Beat scene had formed, with Carr at the center. As Ginsberg put it, “Lou was the glue.”
Carr, Kerouac, Ginsberg and Burroughs explored New York’s grimier underbelly together.
Ginsberg wrote in his journal at the time: “Know these words, and you speak the Carr language: fruit, phallus, clitoris, cacoethes, feces, foetus, womb, Rimbaud.” It was Carr who first introduced Ginsberg to the poetry and the story of 19th century French poet Arthur Rimbaud. Rimbaud would be a major influence on Ginsberg’s poetry.
Ginsberg was plainly fascinated by Carr, whom he viewed as a self-destructive egotist but also as a possessor of real genius.
Carr asked Ginsberg to remove his name from the dedication at the start of "Howl.” The poet agreed. Carr even became a voice of caution in Ginsberg’s life, warning him to “keep the hustlers and parasites at arm’s length.” For many years, Ginsberg would visit the UPI offices and press Carr to cover the various causes with which Ginsberg had allied himself.