Amy Arnsten Scientist
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Amy Arnsten is a member of the following lists: Brown University alumni, Yale University faculty and American neuroscientists.
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Amy Arnsten is an American neuroscientist. She is the Kent Professor of neuroscience and psychology, and a member of the Kavli Institute at Yale University. She studies the unique molecular mechanisms that govern the higher cortical circuits that govern cognition, and the alterations that can lead to cognitive disorders. She has discovered how exposure to uncontrollable stress causes the prefrontal cortex to go "off-line", and how dysregulation of stress signaling pathways with advancing age confers vulnerability to tau pathology, e.g. in Alzheimer's Disease. Her work has identified mechanisms to protect and strengthen prefrontal cortex, leading to the successful translation of two treatments currently in clinical use: guanfacine for disorders of the prefrontal cortex such as ADHD and autism, and prazosin for treating PTSD.
