When her father began a military campaign against the invading army of Alexander the Great, he was accompanied by Drypteis, along with her mother, sister Stateira, and her grandmother Sisygambis.[1] Following the Battle of Issus in 333 BCE, Darius fled, and his family was captured by Macedonian troops. Alexander personally met with the women and promised to provide dowries for Drypteis and Stateira.
Although Darius tried repeatedly to ransom his family, Alexander kept them with him until 331 BCE. At that point Drypteis and her sister were sent to Susa to learn the Greek language.
Drypteis married Hephaestion Amyntoros, a general in Alexander's army in 324 BCE. She was widowed soon after.