Rosina Doyle Wheeler married Edward Bulwer-Lytton (at that time surnamed simply Bulwer) on 29 August 1827. This was against his mother's wishes who withdrew his allowance and he was forced to work for a living.
His writing and efforts in the political arena took a toll upon their marriage, and the couple legally separated in 1836. Her children were taken from her. In 1839, her novel, Cheveley, or the Man of Honour, in which Edward Bulwer-Lytton was bitterly caricatured, was published.
In June 1858, when her husband was standing as parliamentary candidate for Hertfordshire, she appeared at the hustings and indignantly denounced him. She was consequently placed under restraint as insane, but liberated a few weeks later following a public outcry. This was chronicled in her book A Blighted Life. For years she continued her attacks upon her husband's character; she would outlive him by nine years.
They had two children:
Lady Emily Elizabeth Bulwer-Lytton (17 June 1828 – 29 April 1848)
(Edward) Robert Lytton Bulwer-Lytton (8 November 1831 – 24 November 1891); Viceroy of British India from 1876 to 1880