She was married to Jean-Paul-François de Noailles on 25 February 1755. The arranged marriage had been worked out by Adrien-Maurice, 3rd duc de Noailles, who had worked with Chancellor d'Aguesseau.
His first wife, Henriette-Anne-Louise d'Aguesseau, bore him eight children:
*Adrien Paul Louis (17 September 1756 - 7 September 1757).
*Anne Jeanne Baptiste Louise (11 November 1758 - 22 July 1794), who married her cousin the Viscomte d'Ayen.
*Marie-Adrienne-Françoise (2 November 1759 - 24 December 1807), wife of Gilbert Du Motier, marquis de La Fayette.
*A daughter (born and died 11 December 1760).
*Françoise Antoinette Louise (3 September 1763 - 3 August 1788), Comtesse de Thezan du Pourjol.
*Anne Paule Dominique (22 June 1766 - 29 January 1839), Marquise de Pouzols, Marquise de Montagu.
*Angélique Françoise d'Assise Rosalie (1 August 1767 - 16 February 1833), Marquise de Grammont.
L*ouis Gabriel (19 August 1768 - 26 July 1770).
As a member of the royal military the Duke was away from his estates during much of the French revolution.
His absence spared him being arrested along with most of his relatives on orders of Robespierre in May 1794. On 22 July that year his 70 year old mother (the dowager Duchess Françoise de Noailles), his wife (the Duchess Anne-Louise-Henriette), their eldest daughter Louise (the Viscomte d'Ayen [by virtue of marriage to her cousin Marc Antoine de Noaille]), and their second daughter, Adrienne de la Fayette, were condemned to the guillotine; Adrienne was spared at the last moment (possibly due to American intervention- there is debate) only after her grandmother, mother, and sister were beheaded within her sight. The Duke learned of their deaths weeks later; his family lost many other members including two of his uncles and numerous cousins and in-laws during the Revolution.