Tweedy is married to former talent booking agent Sue Miller. Tweedy first met Miller when he was trying to get Uncle Tupelo booked at Cubby Bear, where Miller worked. Miller opened a club in Chicago named Lounge Ax in 1989, and booked Uncle Tupelo for 16 shows over four years. Miller and Tweedy began dating in 1991 and they were married on August 9, 1995. :53,96 Sue was diagnosed with cancer in 2014. In an interview with Rolling Stone, Tweedy was quoted as saying that "she's doing great now." Tweedy also said that music is a healthy distraction in difficult times such as these. They have two sons: Spencer Tweedy (born December 16, 1995) and Sam Tweedy (born December 22, 1999). Spencer was the drummer for pre-teen rock band The Blisters and a new band called Tully Monster. In 2008, Spencer joined Wilco on stage at Madison Square Garden to play drums on their song "The Late Greats," while opening for Neil Young.