Tyler's wife Letitia died of a stroke in the White House in September 1842. His second wife was Julia Gardiner Tyler (July 23, 1820 – July 10, 1889), with whom he had seven children:
David Gardiner Tyler (July 12, 1846 – September 5, 1927),
John Alexander Tyler (April 7, 1848 – September 1, 1883)
Julia Gardiner Tyler Spencer (1849–1871)
Lachlan Tyler (1851–1902)
Lyon Gardiner Tyler (August 24, 1853 – February 12, 1935)
Robert Fitzwalter Tyler (1856–1927)
Pearl Tyler (1860–1947)
In early 1842, Julia was introduced to President John Tyler at a White House reception. Initially the high-spirited and independent-minded northern beauty felt little attraction to the grave, reserved Virginia gentleman, who was thirty years her senior. Julia enjoyed the President's gallant and flattering public attentions but laughingly replied "no, no, no" to his first marriage proposal. But they began seeing each other in January 1843, only a few months after the death of First Lady Letitia Tyler.
they were married on June 26, 1844.