Caesar and Calpurnia married in late 59 BC. Calpurnia was a sixteen-year-old virgin. No children resulted from the union. However, Caesar's daughter Julia, born by his previous wife Cornelia Cinna, was still a child at this time. It was supposed that Calpurnia helped to raise her. Following Caesar's death on the Ides of March (March 15) of 44 BC, Calpurnia delivered all Caesar's personal papers, including will and notes, and most precious possessions to Mark Antony, one of the new leaders of Rome. She did not remarry after the death of Caesar.
According to historical tradition, reflected in some ancient sources, Calpurnia had a premonition of her husband's murder and tried to warn him in vain. She also encouraged Decimus Junius Brutus Albinus to send word to the senate that Caesar was sick on the day of his death, but Caesar refused to lie.