Shortly after arriving in Yan'an, Jiang became involved with Mao Zedong. Some communist leaders were scandalized by the relationship once it became public. At 45, Mao was nearly twice Jiang's age, and Jiang had lived a highly bourgeois lifestyle before coming to Yan'an. Mao was still married to He Zizhen, a lifelong Communist who had previously completed the Long March with him, and with whom Mao had five children. Eventually, Mao arranged a compromise with the other leaders of the CCP: Mao was granted a divorce and permitted to marry Jiang, but she was required to stay out of public politics for thirty years. Jiang abided by this agreement. However, thirty years later, at the beginning of the Cultural Revolution, Jiang became active in politics
On November 28, 1938, Jiang and Mao married in a small private ceremony following approval by the Party's Central Committee. Because Mao's marriage to He had not yet ended, Jiang was reportedly made to sign a marital contract which stipulated that she would not appear in public with Mao as her escort. Jiang and Mao's only child together, a daughter named Li Na, was born in 1940.