(29 July 1914 - 9 April 1919) (his death)
He remarried to Lucile McVey (1890–1925), born in Sedalia, Missouri, a Vitagraph scriptwriter who briefly went under the name Jane Morrow. Sidney Drew added his new wife to his one-reel comedies, acknowledging McVey as both a writer and co-director. As a comedy team, known as Mr. & Mrs. Sidney Drew, the team perfected the situation comedy style that the team of John Bunny and Flora Finch started. Their style of comedy was usually gentle satire on married life, but also poked fun at the world of show business. Sidney took sole credit as director for two five-reel features at Vitagraph, the groundbreaking cross-gender comedy A Florida Enchantment (1914), in which Edith Storey played the leading female role, and the drama Playing Dead (1915), the Drews' only attempt at a "serious" film.
Lucille McVey was a writer at Vitagraph when she met Sidney Drew shortly after his wife's death. They married almost immediately although he was more than twice her age. She scripted and he directed a number of domestic comedies, said to be more subtle and wholesome than those previously filmed. After his death she lost interest in films. She died in 1925 after a lingering illness.