1912 - 2009
Paul Zamecnik American Inventor
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Paul Zamecnik is a member of the following lists: 2009 deaths, Dartmouth College alumni and 1912 births.
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Details
| First Name |
Paul
|
| Last Name |
Zamecnik
|
| Birthday |
30th November, 1911
|
| Died |
27th October, 2009
|
| Nationality |
American
|
| Occupation |
Inventor
|
Paul Charles Zamecnik (22 November 1912 – 27 October 2009) was an American scientist who played a central role in the early history of molecular biology. He was a professor of medicine at Harvard Medical School and a senior scientist at Massachusetts General Hospital. Zamecnik pioneered the in vitro synthesis of proteins and helped elucidate the way cells generate proteins. With Mahlon Hoagland he co-discovered transfer RNA (tRNA). Through his later work, he is credited as the inventor of antisense therapeutics. Throughout his career, Zamecnik earned over a dozen US patents for his therapeutic techniques. Up until his death in 2009 he maintained a lab at MGH where he studied the application of synthetic oligonucleotides (antisense hybrids) for chemotherapeutic treatment of drug resistant and XDR tuberculosis in his later years.
