She married Richard Grenville of Wotton in Buckinghamshire and became the mother of five sons, all of whom served as members of parliament, including Richard Grenville-Temple, 2nd Earl Temple and prime minister George Grenville. One of her daughters was the wife of Pitt the elder and mother of Pitt the younger, both prime ministers of the United Kingdom. Another grandson, William Grenville, 1st Baron Grenville, also became prime minister of the UK.