Elizabeth probably met Robert the Bruce, then Earl of Carrick, at the English court, and they married in 1302 at Writtle, near Chelmsford, Essex, England. Elizabeth would have been about thirteen years old.
On 27 March 1306, Robert and Elizabeth were crowned as King and Queen of Scots at Scone. The coronation took place in defiance of the English claims of suzerainty over Scotland, and the new King sent Elizabeth, with other family members, to Kildrummy Castle for safety under the protection of his brother Nigel (sometimes known as Niall).
After the defeat of the Scots at the Battle of Methven on 19 June 1306, Elizabeth had taken her stepdaughter Marjorie and her husband's sisters Mary and Christian to Kildrummy Castle. The English laid siege to the castle containing the royal party. The siege finally succeeded when the English bribed a blacksmith with "all the gold he could carry" to set fire to the corn store. The victors hanged, drew and quartered Nigel Bruce, along with all the men from the castle. However, the royal ladies under the escort of the Earl of Atholl had already fled.
They were taken from the sanctuary of St. Duthac at Tain by the Earl of Ross, a supporter of the Comyns, and dispatched to King Edward. He imprisoned Bruce's sister Mary and Isabella MacDuff, Countess of Buchan, in wooden cages erected on the walls of Roxburgh and Berwick castles respectively, and then sent Bruce's nine-year-old daughter Marjorie to the nunnery at Watton.
Elizabeth was held under severe conditions of house arrest in England. The Earl of Atholl was hanged and his head displayed on London Bridge.
She was imprisoned for eight years by the English, from October 1306 to July 1308 at Burstwick-in-Holderness, Yorkshire and then transferred to Bisham Manor, Berkshire until March 1312. From there, she was moved to Windsor Castle until October 1312, Shaftesbury Abbey, Dorset until March 1313, Barking Abbey, Essex until March 1314, and Rochester Castle, Kent until June 1314. After the Battle of Bannockburn, she was moved to York while prisoner exchange talks took place. At York, she had an audience with King Edward II of England. Finally, in November 1314, she was moved to Carlisle just before the exchange and her return to Scotland.
Elizabeth had three children who reached adulthood: Matilda, Margaret, and David (the future king David II of Scotland).
Elizabeth died on 27 October 1327 at Cullen Castle, Banffshire and is buried in Dunfermline. King Robert, her husband, died 18 months later.