| Rogue | 2013 | Grace Travis | TV Show |
| Half of a Yellow Sun | 2013 | Olanna (as Thandie Newton) | Movie |
| Good Deeds | 2012 | Lindsey Wakefield (as Thandie Newton) | Movie |
| Line of Duty | 2012 | Roz | TV Show |
| Retreat | 2011 | Kate (as Thandie Newton) | Movie |
| Vanishing on 7th Street | 2010 | Rosemary (as Thandie Newton) | Movie |
| For Colored Girls | 2010 | Orange (as Thandie Newton), Tangie | Movie |
| Huge | 2010 | Kris (as Thandie Newton) | Movie |
| 2012 | 2009 | Laura Wilson (as Thandie Newton) | Movie |
| W. | 2008 | Condoleezza Rice (as Thandie Newton) | Movie |
| How to Lose Friends & Alienate People | 2008 | Thandie Newton (as Thandie Newton) | Movie |
| RocknRolla | 2008 | Stella (as Thandie Newton) | Movie |
| Norbit | 2007 | Kate Thomas (as Thandie Newton) | Movie |
| Run Fatboy Run | 2007 | Libby (as Thandie Newton) | Movie |
| The Pursuit of Happyness | 2006 | Linda (as Thandie Newton) | Movie |
| The Interrogation of Leo and Lisa | 2006 | The Mona Lisa (as Thandie Newton) | Short Film |
| American Dad! | 2005 | Makeva | TV Show |
| Crash | 2004 | Christine (as Thandie Newton) | Movie |
| The Chronicles of Riddick | 2004 | Dame Vaako (as Thandie Newton) | Movie |
| Shade | 2003 | Tiffany (as Thandie Newton) | Movie |
| The Truth About Charlie | 2002 | Regina Lambert (as Thandie Newton) | Movie |
| It Was an Accident | 2000 | Noreen Hurlock (as Thandie Newton) | Movie |
| Mission: Impossible II | 2000 | Nyah Hall (as Thandie Newton) | Movie |
| Beloved | 1998 | Beloved (as Thandie Newton) | Movie |
| Besieged | 1998 | Shandurai (as Thandie Newton) | Movie |
| Gridlock'd | 1997 | Cookie (as Thandie Newton) | Movie |
| In Your Dreams | 1997 | Clare (as Thandie Newton) | TV Movie |
| The Leading Man | 1996 | Hilary Rule (as Thandie Newton) | Movie |
| Jefferson in Paris | 1995 | Sally Hemings (as Thandie Newton) | Movie |
| The Journey of August King | 1995 | Annalees (as Thandie Newton) | Movie |
| Interview with the Vampire: The Vampire Chronicles | 1994 | Yvette (as Thandie Newton) | Movie |
| Loaded | 1994 | Zita (as Thandie Newton) | Movie |
| ER | 1994 | Makemba 'Kem' Likasu | TV Show |
| The Young Americans | 1993 | Rachael Stevens (as Thandie Newton) | Movie |
| Flirting | 1991 | Thandiwe Adjewa (as Thandie Newton) | Movie |
| Pirate Prince | 1991 | Becky Newton (as Thandie Newton) | TV Movie |
| Chicken Run 2 | | Ginger (voice) | Movie |
