Ting-Chao Chou Scientist
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Details
| Birthday |
30th November, 1937
|
| Birthplace |
Hsin-Chu, Taiwan
|
| Occupation |
Scientist
|
Ting-Chao Chou (born 1938 in Taiwan, Chinese name: 周廷潮) is a Chinese American theoretical biologist, pharmacologist, cancer researcher and inventor. His 457 scientific articles have been cited in 26,292 papers in over 754 biomedical journals as of May 5, 2017.[1] He derived the median-effect equation (MEE) from the physico-chemical principle of the mass-action law, and introduced the median-effect plot in 1976.[2,3] With Paul Talalay of the Johns Hopkins University School of Medicine, he derived the combination index equation (CIE) for multiple drug effect interactions, and introduced the concept of combination index (CI) for quantitative definition of synergism (CI<1), additive effect (CI=1), and antagonism (CI>1) using computerized simulations.[3] One original article in Advances in Enzyme Regulation 22:27-55, 1984 by Chou-Talalay on CI has been cited 3,637 times internationally in a broad spectrum of journals.[1] Integration of MEE and CIE resulted in Econo-Green bioresearch and new drug development.[4] This integrated theory and algorithms allow conducting small number of data points, conservation of laboratory animals and reducing the number of patients in clinical trials. Consequently, this allows saving time and cost and resources as well as increasing efficiency an effectiveness in medical, pharmaceutical research and new drug development.[4] With colleagues, T.C. Chou is inventor/co-inventor of 40 U.S. Patents, mainly for anticancer agents.[5]
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