in the spring of 1795, she met Lieutenant William Henry Harrison, in town on military business. Harrison was stationed at nearby Fort Washington. Anna's father thoroughly disapproved of Harrison, largely because he wanted to spare his daughter the hardships of army camp life. Despite his decree that the two stop seeing each other, the courtship flourished behind his back.
They married on November 22, 1795 at the home of Dr. Stephen Wood, treasurer of the Northwest Territory, at North Bend (her father was away in Cincinnati on business). The couple honeymooned at Fort Washington, as Harrison was still on duty. Two weeks later, at a farewell dinner for General "Mad" Anthony Wayne, Symmes confronted his new son-in-law for the first time since their wedding. Addressing Harrison sternly, Symmes demanded to know how he intended to support a family with Anna. Harrison responded "by my sword, and my own right arm, sir." Not until his son-in-law had achieved fame on the battlefield did Symmes come to accept him.
The couple apparently had a happy marriage despite the succession of tragedies in the untimely deaths of five of their grown children.
Elizabeth Bassett Harrison (29 September 1796-27 September 1846)
John Cleves Symmes Harrison (28 October 1798-30 October 1830)
Lucy Singleton Harrison (5 September 1800-7 April 1826)
William Henry Harrison Jr (3 Sept 1802-6 Sept 1838); married to Jane
Irwin Harrison
John Scott Harrison (4 October 1804-25 May 1878)
Benjamin Harrison (5 May 1806-9 June 1840)
Mary Symmes Harrison (28 January 1809-16 November 1842)
Carter Bassett Harrison (26 Oct 1811-12 Aug 1839)
Anna Tuthill Harrison (28 October 1813-5 July 1845)
James Findlay Harrison (15 May 1814-6 April 1817)