| One Life to Live | 1968 | Victor Lord | TV Show |
| The Name of the Game | 1968 | Dr. Witherton | TV Show |
| Daring Game | 1968 | Dr. Henry L. Carlyle | Movie |
| "Hallmark Hall of Fame" Barefoot in Athens | 1966 | Lycon | TV Movie |
| Another World | 1964 | Jim Matthews / James 'Jim' Matthews | TV Show |
| Mr. Broadway | 1964 | Harold Draper | TV Show |
| Violent Midnight | 1963 | Adrian Benedict | Movie |
| The Doctors and the Nurses | 1962 | Dr. Roger Bartlett | TV Show |
| Car 54, Where Are You? | 1961 | Gordon Pennington | TV Show |
| The Defenders | 1961 | Alfred Carter Sr. | TV Show |
| The Barbara Stanwyck Show | 1960 | Bill Mowry | TV Show |
| Thriller | 1960 | Douglas Kilburn | TV Show |
| Dow Hour of Great Mysteries | 1960 | Dr. Wells | TV Show |
| Moment of Fear | 1960 | | TV Show |
| Play of the Week | 1959 | Dr. Bruner | TV Show |
| The DuPont Show with June Allyson | 1959 | Stanley Sidney | TV Show |
| The Twilight Zone | 1959 | Peter Selden | TV Show |
| 77 Sunset Strip | 1958 | James McCullough | TV Show |
| Girl on the Run | 1958 | James McCullough / Ralph Graham | Movie |
| The Further Adventures of Ellery Queen | 1958 | | TV Show |
| The Investigator | 1958 | Charlie Redman | TV Show |
| The Sad Sack | 1957 | Major General Vanderlip | Movie |
| Have Gun - Will Travel | 1957 | Colonel Benjamin Nunez | TV Show |
| Perry Mason | 1957 | Dr. Morris | TV Show |
| Wagon Train | 1957 | Colonel Charles E. Beauchamp | TV Show |
| Harbormaster | 1957 | Michael Benson | TV Show |
| The Adventures of McGraw | 1957 | Dillon Brent | TV Show |
| The Californians | 1957 | Father Holzer | TV Show |
| That Night! | 1957 | Dr. Bernard Fischer | Movie |
| True Story | 1957 | Jack Parker / Dr. George Edwards | TV Show |
| Autumn Leaves | 1956 | Dr. Malcolm Couzzens | Movie |
| Beyond a Reasonable Doubt | 1956 | Jonathan Wilson | Movie |
| The Eddy Duchin Story | 1956 | Sherman Wadsworth | Movie |
| As the World Turns | 1956 | Dr. Field | TV Show |
| Playhouse 90 | 1956 | Reagan / Charley Potter | TV Show |
| Wire Service | 1956 | David | TV Show |
| The Joseph Cotten Show: On Trial | 1955 | Elliott Simpson | TV Show |
| Climax! | 1954 | Father / Bert / Dr. Giffin / ... | TV Show |
| Inner Sanctum | 1954 | Host | TV Show |
| Lady in the Dark | 1954 | Dr. Alexander Brooks | TV Movie |
| The United States Steel Hour | 1953 | Horace Killman | TV Show |
| You Are There | 1953 | King Solomon / Crito / Thomas Jefferson | TV Show |
| The Revlon Mirror Theater | 1953 | | TV Show |
| Omnibus | 1952 | Charles Francis Adams (segment "The Lives of Henry Adams and Charles Francis Adams Jr.") / (segment "Antigone") | TV Show |
| Curtain Call | 1952 | | TV Show |
| Short Short Dramas | 1952 | | TV Show |
| Encounter | 1952 | Jeremiah Bracken | TV Show |
| The Gulf Playhouse | 1952 | Alvin Boyle | TV Show |
| A Place in the Sun | 1951 | Anthony Vickers | Movie |
| Goodyear Playhouse | 1951 | | TV Show |
| Love of Life | 1951 | Timothy McCauley | TV Show |
| Schlitz Playhouse | 1951 | Elliott Simpson | TV Show |
| Under the Gun | 1951 | Milo Bragg | Movie |
| Let's Dance | 1950 | Timothy Bryant | Movie |
| The Kid from Texas | 1950 | Roger Jameson | Movie |
| Three Husbands | 1950 | Arthur Evans | Movie |
| Armstrong Circle Theatre | 1950 | Lesage | TV Show |
| Danger | 1950 | | TV Show |
| Pulitzer Prize Playhouse | 1950 | Cliff Mettinger | TV Show |
| All the King's Men | 1949 | Adam Stanton | Movie |
| Chicago Deadline | 1949 | Edgar 'Blacky' Franchot | Movie |
| Reign of Terror | 1949 | Napoleon Bonaparte (voice, uncredited) | Movie |
| The Reckless Moment | 1949 | Ted Darby | Movie |
| The Red Pony | 1949 | Mr. Fred Tiflin | Movie |
| Enchantment | 1948 | Marchese Del Laudi | Movie |
| Fighter Squadron | 1948 | Brig. Gen. Mel Gilbert | Movie |
| Joan of Arc | 1948 | Father Massieu - Her Bailiff | Movie |
| The Philco-Goodyear Television Playhouse | 1948 | Lincoln Venner / Benedict Arnold | TV Show |
| Studio One in Hollywood | 1948 | Mac Taylor / Nordlund / Hal Manning / ... | TV Show |
| Kraft Theatre | 1947 | Robert Carter | TV Show |
| Home, Sweet Homicide | 1946 | Mr.Wallace Sanford (as John Shepperd) | Movie |
| Strange Triangle | 1946 | Earl Huber (as John Shepperd) | Movie |
| The Fighting Guerrillas | 1943 | Lieutenant. Aleksa Petrovic (as John Shepperd) | Movie |
| Rings on Her Fingers | 1942 | Tod Fenwick (as John Shepperd) | Movie |
| Ten Gentlemen from West Point | 1942 | Henry Clay (as John Shepperd) | Movie |
| Dr. Renault's Secret | 1942 | Dr. Larry Forbes (as John Shepperd) | Movie |
| The Loves of Edgar Allan Poe | 1942 | Edgar Allan Poe (as John Shepperd) | Movie |
| Belle Starr | 1941 | Ed Shirley (as John Shepperd) | Movie |
| Remember the Day | 1941 | Dewey Roberts (as John Sheppard) | Movie |
| The Men in Her Life | 1941 | Roger Chevis (as John Shepperd) | Movie |
| Cadet Girl | 1941 | Bob Mallory (as John Shepperd) | Movie |
| Know for Sure | 1941 | Dr. Morton (uncredited) | Short Film |
| Dr. Kildare's Strange Case | 1940 | Dr. Gregory 'Greg' Lane | Movie |
| Flight Command | 1940 | Lieut. Jerry Banning | Movie |
| The Mortal Storm | 1940 | Narrator (uncredited) | Movie |
| Congo Maisie | 1940 | Dr. John McWade | Movie |
| Mighty Hunters | 1940 | Narrator (voice, uncredited) | Short Film |
| Tom Thumb in Trouble | 1940 | Narrator / Tom Thumb's Father (voice, uncredited) | Short Film |
| A Way in the Wilderness | 1940 | Dr. Joseph Goldberger | Short Film |
| Old Glory | 1939 | Paul Revere (voice, uncredited) | Short Film |
| Fast Company | 1938 | Ned Morgan | Movie |
| That Mothers Might Live | 1938 | Dr. Semmelweis (as Sheppard Strudwick) | Short Film |
| Joaquin Murrieta | 1938 | Joaquin Murrieta (as Sheppard Strudwick) | Short Film |
